Evidence & Resources

Late emergence of pathological oscillatory activity in the retina of the ...

Photoreceptor degeneration is a leading cause of blindness in hereditary diseases like Retinitis pigmentosa (RP) and non...

Late gene therapy limits the restoration of retinal function in a ...

Dec 12, 2023·We conclude that gene replacement therapies delivered after 50% rod loss are unlikely to restore visual fun...

(PDF) Optogenetic Therapy for VisualRestoration

provide visualrestorationforlate-stageretinal degeneration, regardless of the genotype. Bi et al. first reported in 2006 ...

JCI - It’s never toolateto save aphotoreceptor

Here, we tested the latter hypothesis and developed a mouseRPmodel that permitsrestorationof the mutant gene in all dise...

PII: S1350-9462(98) 00032-9

6.3.3.TreatmentoflatestageRPwill provide a limited improvement in vision. It seems possible that the blindness of thelat...

Long-termrestorationof visual function in end-stageretinal... | PNAS

To model the extensivephotoreceptorloss seen in end-stageRP, the rd1 mouse was used. These mice have a nonsense mutation...

Late-stage rescue of visually guided behavior in the context of a ...

Feb 23, 2022·We used a Pde6b-deficient RP gene therapy mouse model to test whether treatment at late disease stages can ...