Evidence & Resources

Late emergence of pathological oscillatory activity in the retina of the ...

Photoreceptor degeneration is a leading cause of blindness in hereditary diseases like Retinitis pigmentosa (RP) and non...

Late gene therapy limits the restoration of retinal function in a ...

Dec 12, 2023·We conclude that gene replacement therapies delivered after 50% rod loss are unlikely to restore visual fun...

(PDF) Optogenetic Therapy for VisualRestoration

provide visualrestorationforlate-stageretinal degeneration, regardless of the genotype. Bi et al. first reported in 2006 ...

JCI - It’s never toolateto save aphotoreceptor

Here, we tested the latter hypothesis and developed a mouseRPmodel that permitsrestorationof the mutant gene in all dise...

PII: S1350-9462(98) 00032-9

6.3.3.TreatmentoflatestageRPwill provide a limited improvement in vision. It seems possible that the blindness of thelat...

Long-termrestorationof visual function in end-stageretinal... | PNAS

To model the extensivephotoreceptorloss seen in end-stageRP, the rd1 mouse was used. These mice have a nonsense mutation...

Late-stage rescue of visually guided behavior in the context of a ...

Feb 23, 2022·We used a Pde6b-deficient RP gene therapy mouse model to test whether treatment at late disease stages can ...

PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical...

Late-stagePRPF31-RPis characterized by the permanent loss ofphotoreceptorsand significant vision loss. In this stage of ...

Persistent remodeling and neurodegeneration in late-stage ...

Photoreceptor degeneration can be caused by numerous mechanisms including hereditary diseases directly affecting the pho...

Restoration of Cone Photoreceptor Function in Retinitis Pigmentosa

Sep 6, 2017·Taken together, these findings suggest that cone dormancy in end-stage RP might be driven by starvation for ...